Philippines TB transmission report
Whole genome sequencing analysis of Mycobacterium tuberculosis reveals circulating strain types and drug-resistance mutations in the Philippines
Conducted whole-genome sequencing on 732 M. tuberculosis isolates across the Philippines, revealing predominance of L1 Manila strain and emerging L4 drug-resistant lineages.
Identified MDR-TB and XDR-TB clusters linked to prison transmission and novel resistance mutations using genome-wide association and phylogenetic analyses.
Developed genomic surveillance insights using mutation frequency data and time-scaled Bayesian phylogenetics to assess transmission dynamics and drug resistance evolution.
Detected novel bedaquiline resistance mutations within prison-derived isolates, highlighting urgent public health concerns in carceral settings.
Phylogenetic tree of the 724 M. tuberculosis study isolates constructed using 34,260 SNPs